Jason Bates, Ph.D.
Departments of Medicine, Molecular Physiology & Biophysics, Electrical & Biomedical Engineering
University of Vermont
“Ventilating the injured lung as an engineering problem”
Acute respiratory distress syndrome (ARDS) is a non-cardiogenic form of pulmonary edema that is often fatal. Management of ARDS generally involves mechanical ventilation, which itself can cause potentially fatal ventilator-induced lung injury (VILI). Minimizing the tissue stresses and strains wrought by mechanical ventilation is essentially an engineering problem. Our research is aimed at solving this problem by finding a cost function defining how much injury is caused by a given regimen of mechanical ventilation in a given lung. Physiological measurements together with images from a number of modalities in mice suggest that the key to preventing VILI is to avoid repetitively re-opening regions of the lung that collapse with each expiration. However, both the collapse itself and the injury it causes are time-dependent processes. We have been able to recapitulate the dynamics of these processes in computational models, which may thus provide the basis for an injury cost function that could help lead to optimally safe patient-specific strategies for mechanical ventilation in ARDS.
Jason H.T. Bates obtained his B.Sc. in Physics at the University of Canterbury in 1977 and his Ph.D. in Medicine in 1981 from the University of Otago, both in New Zealand. He is currently Professor of Medicine, Molecular Physiology & Biophysics, and Electrical & Biomedical Engineering at the University of Vermont. Dr. Bates is also Deputy Editor for the Journal of Applied Physiology, a Fellow of AIMBE and BMES, and a Senior Member of IEEE-EMBS.