Tzung Hsiai, M.D., Ph.D.
University of California, Los Angeles
"Convergence of Engineering and Medicine: Light-Sheet Imaging to Elucidate Blood Flow from Cardiac Development to Atherosclerosis"
During cardiac development, peristaltic contraction of the embryonic heart tube produces time-varying hemodynamic forces and pressure gradients across the atrioventricular canal. By using advanced imaging, we recapitulated flow-mediated Notch-Nrg1-ErbB2 signaling to initiate endocardial trabeculation for contractile function. During the aging process, blood flow modulates both metabolic and mechanical effects on the vessel wall to initiate atherosclerosis. By using advanced sensors, we elucidated 1) PKCe-PFKPB3-mediated glycolytic pathway to promote vascular regeneration, and 2) PPARg-SCD1-mediated fatty acid metabolites to promote atheroprotection. Overall, converging engineering and medicine provides fundamental insights into flow-mediated biomarkers with therapeutic targets.
Dr. Hsiai is the Professor of Medicine (Cardiology) and Bioengineering. He received his undergraduate education from Columbia University and his MD from the University of Chicago. He completed his internship, residency and NIH-funded cardiovascular fellowship at UCLA School of Engineering and Medicine, where he developed micro-sensors to study mechano-transduction underlying vascular diseases. His group is instrumental in promoting team science that led to the LA PRISM Program between UCLA Bioinformatics and USC Environmental Health. His multi-disciplinary team has converged NIH-funded collaborations with Caltech, Mayo Clinic, Stanford, USC, and UCSD. He has served as the Chair of the American Physiological Society Joint Meeting with Biomedical Engineering Society, Chair of NIH 3-D printing study section, and member of AHA Scientific Planning Committee. He was elected to the American Society for Clinical Investigation, Member of National Institutes of Health Bioengineering, Biotechnology, and Surgical Science Study Section, Fellow of American College of Cardiology, Fellow of American Heart Association, College Fellow of American Institute of Medical and Biological Engineering (AIMBE), and the recipient of an American Heart Association John J. Simpson Outstanding Research Achievement Award, USC School of Engineering Junior Faculty Research Award, and UCLA SEAS Distinguished Young Alumnus Award.