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Pioneering single cell proteomics
The article Transformative Opportunities for Single-Cell Proteomics, which is research from BioE Assistant Professor Nikolai Slavov's Laboratory, is featured on the cover of the Journal of Proteome Research, a leading protemics journal published by the American Chemical Society.
Many pressing medical challenges, such as diagnosing disease, enhancing directed stem-cell differentiation, and classifying cancers, have long been hindered by limitations in our ability to quantify proteins in single cells. Mass spectrometry (MS) is poised to transcend these limitations by developing powerful methods to routinely quantify thousands of proteins and proteoforms across many thousands of single cells. We outline specific technological developments and ideas that can increase the sensitivity and throughput of single-cell MS by orders of magnitude and usher in this new age. These advances will transform medicine and ultimately contribute to understanding biological systems on an entirely new level.