You are here

A.Asthagiri@northeastern.edu

Profile

Biography

The Asthagiri lab elucidates design principles for engineering living cells and tissues. These design principles provide a foundation for tissue engineering and regenerative medicine. The implications extend beyond engineering artificial organ replacements. Synthetic multicellular structures that mimic their natural counterparts provide better platforms for drug discovery and screening. In addition, elucidating how multicellular structures assemble provides deeper insights into how these structures fall apart in diseases, such as cancer. Understanding the disassembly of multicellular structures sheds new insights into cancer development and helps to identify therapeutic strategies to re-shape diseased tissue.

Education

  • B.S. with distinction (Chemical Engineering) Cornell University, 1995
  • Ph.D. (Chemical Engineering) Massachusetts Institute of Technology, 2000
  • Postdoctoral Fellow Harvard Medical School, 2000-2001

Research & Scholarship Interests

cell and tissue engineering, quantitative principles of cancer cell biology and developmental biology
Affiliated With

Department Research Areas

College Research Initiatives

Selected Publications

  • D.F. Milano, R.J. Natividad, Y. Saito, C.Y. Luo, S.K. Muthuswamy, A.R. Asthagiri, Positive Quantitative Relationship Between EMT and Contact-Initiated Sliding on Fiber-Like Tracks, Biophysical Journal, 111(7), 2016, 1569-1574
  • D.F. Milano, N.A. Ngai, S.K. Muthuswamy, A.R. Asthagiri, Regulators of Metastasis Modulate the Migratory Response to Cell Contact Under Spatial Confinement, Biophysical Journal, 110(8), 2016, 1886-1895
  • D.I. Walsh III, M.L. Lalli, J.M. Kassas, A.R. Asthagiri, S.K. Murthy, Cell Chemotaxis on Paper for Diagnostics, Analytical Chemistry, 87(11), 2015, 5505-5510
  • M.L. Lalli, A.R. Asthagiri, Collective Migration Exhibits Greater Sensitivity but Slower Dynamics of Alignment to Applied Electric Fields, Cellular and Molecular Bioengineering, 8(2), 2015, 247-257
  • K. Blogovic, E.S. Gong, D. F. Milano, R.J. Natividad, A.R. Asthagiri, Engineering Cell-Cell Signaling, Current Opinion in Biotechnology, 24(5), 2013, 940-947
  • K. Kushiro, A.R. Asthagiri, Modular Design of Micropattern Geometry Achieves Combinatorial Enhancements in Cell Motility, Langmuir, 28(9), 2012, 4357-4362
  • J.H. Kim, A.R. Asthagiri, Matrix Stiffening Sensitizes Epithelial Cells to EGF and Enables the Loss of Contact Inhibition of Proliferation, Journal of Cell Science, 124, 2011, 1280-1287
  • J.H. Kim, L.J. Dooling, A.R. Asthagiri, Intercellular Mechanotransduction During Multicellular Morphodynamics, Royal Society Interface, 7(3), 2010, 341-350
  • C.A. Giurumescu, P.W. Sternberg, A.R. Asthagiri, Predicting Phenotypic Diversity and the Underlying Quantitative Molecular Transitions, PLoS Computational Biology, 5(4), 2009, 1-13
  • J.H. Kim, K. Kushiro, N.A. Graham, A.R. Asthagiri, Turnable Interplay Between Epidermal Growth Factor and Cell-Cell Contact Governs the Spatial Dynamics of Epithelial Growth, Proceedings of the National Academy of Sciences USA, 106(27), 2009, 11149-11153
See Google Scholar Profile for all publications »

Related News

April 28, 2016

BioE Associate Professor Anand Asthagiri explores the biophysics behind the spread of breast cancer, providing hope for future treatments and early diagnosis. Source: News @ Northeastern Metas­...

February 17, 2016

Mark Lalli was honored with the 2015 Graduate Seminar Award. Lalli is a 4th year PhD student in Chemical Engineering under guidance of Anand Asthagiri. The winning seminar was titled "Impact of...

May 26, 2015

Bioengineering PhD student David Walsh's research on "Cell Chemotaxis on Paper for Diagnostics" was recently published in Analytical Chemistry.