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Penny Beuning

Associate Professor, Chemistry and Chemical Biology
Affiliated Faculty, Bioengineering
06 Hurtig Hall
360 Huntington Avenue
Boston, MA 02115


2000 Ph.D. University of Minnesota
1994 B.A. Macalester College, St. Paul, Minnesota

Research & Scholarship Interests

Chemical biology and biotechnology
Affiliated With

Department Research Areas

Honors & Awards

  • 2012, American Cancer Society Research Scholar Award
  • 2009, National Science Foundation CAREER Award
  • 2009, Cottrell Scholar Award

Selected Publications

  • D.A. Murison, J.N. Ollivierre, Q. Huang, D.E. Budil, P.J. Beuning, Altering the N-Terminal Arms of the Polymerase Manager Protein UmuD Modulates Protein Interactions, PLoS One, 12(3), 2017, e0173388
  • M. Nabuan Naufer, D.A. Murison, I. Rouzina, P.J. Beuning, M.C. Williams, Single-Molecule Mechanochemical Characterization of E. Coli pol III Core Catalytic Activity, Protein Science, 26(7), 2017, 1413-1426
  • L.A. Hawver, M. Tehrani, N. Antczak, D. Kania, S. Muser, J. Sefcikova, P.J. Beuning, Point Mutations in Escherichia coli DNA pol V that Confer Resistance to Non-Cognate DNA Damage also Alter Protein-protein Interactions, Mutation Research—Fundamental and Molecular Mechanisms of Mutagenesis, 780, 2015, 1-14
  • P. Nevin, X. Lu, K. Zhang, J.R. Engen, P.J. Beuning, Non-Cognate DNA Damage Prevents Formation of Active Conformation of Y-family DNA Polymerases DinB and Pol Kappa, The FEBS Journal, 282, 2015, 2646-2660
  • J. Fang, P. Nevin, V. Kairys, C. Venclovas, J.R. Engen, P.J. Beuning, Conformational Analysis of Processivity Clamps in Solution Demonstrates That Tertiary Structure Does not Correlate with Protein Dynamics, Structure, 22, 2014, 572-581
  • J.M. Walsh, P.J. Ippoliti, E.A. Ronayne, E. Rozners, P.J. Beuning, Discrimination Against Major Groove Adducts by Y Family Polymerases of the DinB Subfamily, DNA Repair, 12, 2013, 713-722
  • K.R. Chaurasiya, C. Ruslie, M.C. Silva, L. Voortman, P. Nevin, S. Lone, P.J. Beuning, M.C. Williams, Polymerase Manager Protein UmuD Directly Regulates E. coli DNA Polymerase III Binding to ssDNA, Nucleic Acids Research, 41, 2013, 8959-8968

Related News

August 21, 2018

BioE Professor Jeffrey Ruberti (co-PI) along with bioengineering affiliated and College of Science faculty, including Professor Mark Williams (PI), and Associate Professors Penny Beuning (co-PI), Meni Wanunu (co-PI), and Ke Zhang (co-PI) were awarded a $1M NSF grant for the "Acquisition of a Lumick's SuperC-TRAP correlative optical tweezers and fluorescence microscope (CTFM) system."

March 22, 2016

23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.