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Penny Beuning

Associate Professor, Chemistry and Chemical Biology
Affiliated Faculty, Bioengineering
06 Hurtig Hall
360 Huntington Avenue
Boston, MA 02115


2000 Ph.D. University of Minnesota
1994 B.A. Macalester College, St. Paul, Minnesota

Research & Scholarship Interests

Chemical biology and biotechnology

Honors & Awards

  • 2012, American Cancer Society Research Scholar Award
  • 2009, National Science Foundation CAREER Award
  • 2009, Cottrell Scholar Award

Selected Publications

  • R. Parasuram, T.A. Coulther, J.M. Hollander, E. Keston-Smith, M.J. Ondrechen, P.J. Beuning, Prediction of Active Site and Distal Residues in E. coli DNA Polymerase III Alpha Polymerase Activity, Biochemistry, 57(7), 2018, 1063–1072
  • N.M. Antczak, M. Packer, X. Lu, K. Zhang, P.J. Beuning, Human Y-family DNA Polymerase Kappa is more Tolerant to Changes in its Active Site Loop than its Ortholog E. coli DinB, Chemical Research in Toxicology, 30(11), 2017, 2002–2012
  • D.A. Murison, R.C. Timson, B.N. Koleva, M. Ordazzo, P.J. Beuning, Identification of the Dimer Exchange Interface of the Bacterial DNA Damage Response Protein UmuD, Biochemistry, 56, 2017, 4773-4785
  • D.A. Murison, J.N. Ollivierre, Q. Huang, D.E. Budil, P.J. Beuning, Altering the N-Terminal Arms of the Polymerase Manager Protein UmuD Modulates Protein Interactions, PLoS One, 12(3), 2017
  • M. Nabuan Naufer, D.A. Murison, I. Rouzina, P.J. Beuning, M.C. Williams, Single-Molecule Mechanochemical Characterization of E. coli pol III Core Catalytic Activity, Protein Science, 26(7), 2017, 1413-1426
  • P. Nevin, X. Lu, K. Zhang, J.R. Engen, P.J. Beuning, Non-Cognate DNA Damage Prevents Formation of Active Conformation of Y-family DNA Polymerases DinB and Pol Kappa, The FEBS Journal, 282, 2015, 2646-2660

Related News

June 27, 2019

ECE Professor Deniz Erdogmus (co-PI) and affiliated BioE Professors Mary Jo Ondrechen (PI) and Penny Beuning (co-PI) were awarded a $600K NSF grant for "Mining for mechanistic information to predict protein function".

August 21, 2018

BioE Professor Jeffrey Ruberti (co-PI) along with bioengineering affiliated and College of Science faculty, including Professor Mark Williams (PI), and Associate Professors Penny Beuning (co-PI), Meni Wanunu (co-PI), and Ke Zhang (co-PI) were awarded a $1M NSF grant for the "Acquisition of a Lumick's SuperC-TRAP correlative optical tweezers and fluorescence microscope (CTFM) system."

March 22, 2016

23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.