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n.slavov@northeastern.edu

Profile

Biography

Nikolai Slavov received his undergraduate education from the Massachusetts Institute of Technology (MIT) in 2004. He pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. He discovered a simple mechanism that can account for the growth-rate dependent transcriptional responses across a wide range of growth conditions and growth rates  (Slavov and Botstein, 2011Slavov et al., 2011). After defending his dissertation in 2010, Nikolai Slavov began a postdoctoral project in the van Oudenaarden laboratory at MIT, aiming to understand the Warburg effect, a hallmark of cancer cells characterized by the fermentation of glucose in the presence of enough oxygen to support respiration. This work demonstrated that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival and that, contrary to expectations and decades-long assumptions, exponential growth at a constant rate can represent not a single metabolic/physiological state but a continuum of changing states characterized by different metabolic fluxes (Slavov et al., 2014). Following a lead from these experiments, Nikolai Slavov obtained direct evidence for differential stoichiometry among core ribosomal proteins in unperturbed wild-type cells (Slavov et al., 2015). His findings support the existence of ribosomes with distinct protein composition and physiological function that represent an explored layer of regulating gene expression.  Most recently, the Slavov laboratory has devloped a method for Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS) and used it to quantify proteome heterogeneity during cell differentiation.

Education

  • PhD (2010), Botstein Laboratory, Princeton University
  • BS (2004), Biology, Massachusetts Institute of Technology

Research & Scholarship Interests

ribosome-mediated translational regulation, single cell proteomics, cell growth and differentiation, statistical inference, single cell mass-spectrometry, cell metabolism; quantitative systems biology; computational biology, bioinformatics, proteomics and genomics;
Affiliated With

Department Research Areas

Honors & Awards

  • NIH Director’s New Innovator Award
  • SPARC Award from the Broad Institute of MIT and Harvard
  • Princeton University Dean's Award
  • IRCSET Postgraduate Research Fellowship
  • Finalist in the Young European Entrepreneur Competition
  • Princeton Graduate Fellowship
  • MIT Undergraduate Fellowship
  • Eureka Fellowship for Academic Excellence
  • Bronze Medal in the 31st International Chemistry Olympiad 
  • National Diploma for Exceptional Achievements in Chemistry

Teaching Interests

Professional Affiliations

  • Broad Institute of MIT & Harvard 
  • American Society for Mass Spectrometry (ASMS)
  • American Society for Cell Biology (ASCB)
  • Genetics Society of America (GSA)

Selected Publications

 

See Google Scholar Profile for all publications »

Related News

May 22, 2017

Research from BioE Assistant Professor Nikolai Slavov's laboratory is highlighted in The Scientist in the article entitled "How Statistics Weakened mRNA’s Predictive Power".

April 10, 2017

Recently the Slavov lab developed Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS) , and validated its ability to identify distinct human cancer cell types based on their proteomes. They used...

October 11, 2016

BioE Assistant Professor Nikolai Slavov was awarded the National Institutes of Health Director's New Innovator Award and a $2.35M grant to study "Ribosome-Mediated Translational Regulation during Stem Cell Differentiation".