You are here

n.slavov@northeastern.edu

Profile

Nikolai Slavov

Assistant Professor, Bioengineering
Affiliated Faculty, Biology
617.373.5473
Mugar Life Sciences Building, Office 334
360 Huntington Avenue
Boston, MA 02115

Biography

Nikolai Slavov received his undergraduate education from the Massachusetts Institute of Technology (MIT) in 2004. He pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. He discovered a simple mechanism that can account for the growth-rate dependent transcriptional responses across a wide range of growth conditions and growth rates  (Slavov and Botstein, 2011Slavov et al., 2011). After defending his dissertation in 2010, Nikolai Slavov began a postdoctoral project in the van Oudenaarden laboratory at MIT, aiming to understand the Warburg effect, a hallmark of cancer cells characterized by the fermentation of glucose in the presence of enough oxygen to support respiration. This work demonstrated that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival and that, contrary to expectations and decades-long assumptions, exponential growth at a constant rate can represent not a single metabolic/physiological state but a continuum of changing states characterized by different metabolic fluxes (Slavov et al., 2014). Following a lead from these experiments, Nikolai Slavov obtained direct evidence for differential stoichiometry among core ribosomal proteins in unperturbed wild-type cells (Slavov et al., 2015). His findings support the existence of ribosomes with distinct protein composition and physiological function that represent an explored layer of regulating gene expression.  

Education

  • PhD (2010), Botstein Laboratory, Princeton University
  • BS (2004), Biology, Massachusetts Institute of Technology

Research & Scholarship Interests

ribosome-mediated translational regulation, coordination of cell growth and differentiation; statistical inference, mass-spectrometry; cell metabolism; quantitative systems biology; computational biology, bioinformatics, proteomics and genomics;
Affiliated With

Department Research Areas

Honors & Awards

  • NIH Director’s New Innovator Award
  • SPARC Award from the Broad Institute of MIT and Harvard
  • Princeton University Dean's Award
  • IRCSET Postgraduate Research Fellowship
  • Finalist in the Young European Entrepreneur Competition
  • Princeton Graduate Fellowship
  • MIT Undergraduate Fellowship
  • Eureka Fellowship for Academic Excellence
  • Bronze Medal in the 31st International Chemistry Olympiad 
  • National Diploma for Exceptional Achievements in Chemistry

Professional Affiliations

  • Broad Institute of MIT & Harvard 
  • American Society for Cell Biology (ASCB)
  • Genetics Society of America (GSA)

Selected Publications

See Google Scholar Profile for all publications »

Related News

October 11, 2016

BioE Assistant Professor Nikolai Slavov was awarded the National Institutes of Health Director's New Innovator Award and a $2.35M grant to study "Ribosome-Mediated Translational Regulation during Stem Cell Differentiation".

March 22, 2016

23 COE faculty and affiliates were recipients of FY17 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing over $600K dollars of investment in research.

December 10, 2015

BioE Assistant Professor Nikolai Slavov's research was featured in Trends in Biochemical Sciences for "All Ribosomes Are Created Equal. Really?"