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n.slavov@northeastern.edu

Profile

Biography

Nikolai Slavov received his undergraduate education from the Massachusetts Institute of Technology (MIT) in 2004. He pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. He discovered a simple mechanism that can account for the growth-rate dependent transcriptional responses across a wide range of growth conditions and growth rates  (Slavov and Botstein, 2011Slavov et al., 2011). After defending his dissertation in 2010, Nikolai Slavov began a postdoctoral project in the van Oudenaarden laboratory at MIT, aiming to understand the Warburg effect, a hallmark of cancer cells characterized by the fermentation of glucose in the presence of enough oxygen to support respiration. This work demonstrated that aerobic glycolysis can reduce the energy demands associated with respiratory metabolism and stress survival and that, contrary to expectations and decades-long assumptions, exponential growth at a constant rate can represent not a single metabolic/physiological state but a continuum of changing states characterized by different metabolic fluxes (Slavov et al., 2014). Following a lead from these experiments, Nikolai Slavov obtained direct evidence for differential stoichiometry among core ribosomal proteins in unperturbed wild-type cells (Slavov et al., 2015). His findings support the existence of ribosomes with distinct protein composition and physiological function that represent an explored layer of regulating gene expression.  Most recently, the Slavov laboratory developed a high-throughput method for Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS) and used it to quantify proteome heterogeneity during cell differentiation.

Education

  • PhD (2010), Botstein Laboratory, Princeton University
  • BS (2004), Biology, Massachusetts Institute of Technology

Research & Scholarship Interests

Rationally engineered directed differentiation; single cell proteomics and genomics; ribosome-mediated translational regulation; statistical inference, single cell mass-spectrometry, cell metabolism; quantitative systems biology; computational biology
Affiliated With

Department Research Areas

Honors & Awards

  • NIH Director’s New Innovator Award
  • SPARC Award from the Broad Institute of MIT and Harvard
  • Princeton University Dean's Award
  • IRCSET Postgraduate Research Fellowship
  • Finalist in the Young European Entrepreneur Competition
  • Princeton Graduate Fellowship
  • MIT Undergraduate Fellowship
  • Eureka Fellowship for Academic Excellence
  • Bronze Medal in the 31st International Chemistry Olympiad 
  • National Diploma for Exceptional Achievements in Chemistry

Teaching Interests

Professional Affiliations

  • Broad Institute of MIT & Harvard 
  • American Society for Mass Spectrometry (ASMS)
  • American Society for Cell Biology (ASCB)
  • Genetics Society of America (GSA)

Selected Publications

See Google Scholar Profile for all publications »

Related News

June 13, 2018

The 1st Single Cell Proteomics (SCP) Conference was recently held at Northeastern which focused on demonstrating the feasibility of quantifying thousands of proteins in single cells by mass-spectrometry

May 1, 2018

Congratulations to all the winners of the faculty and staff awards, and to everyone for their hard work and dedication during the 2017-2018 academic school year. Faculty Fellow Guohao Dai, BioE...

April 19, 2018

Research pioneered in BioE Assistant Professor Nikolai Slavov's laboratory on a mass-spec method for quantifying proteins in single cells (SCoPE-MS) was highlighted on GenomeWeb.