BioE Assistant Professor Ambika Bajapayee along with COS Assistant Professor Justin Crane propose to increase resilience in the aging population by developing novel ways of treating osteoarthritis (OA), the most common musculoskeletal disease and the leading cause of immobility.
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- PhD, Mechanical Engineering, Massachusetts Institute of Technology, 2015
- MEng, Mechanical Engineering, Massachusetts Institute of Technology, 2007
- BS, Mechanical Engineering, University of Delhi, 2006
- Osteoarthritis Research Society International (OARSI)
- Orthopaedic Research Society (ORS)
- Nano Engineering for Medicine and Biology (NEMB, ASME)
- A.G. Bajpayee, A.J. Grodzinsky, Cartilage Targeting Drug Delivery: Can Electrostatic Interactions help?, Nature Rheumatology Reviews, 2017 LINK
- A.G. Bajpayee, M.A. Quadir, P.T. Hammond, A.J. Grodzinsky, Charge Based Intra-cartilage Delivery of Single Dose Dexamethasone Using Avidin Nano-carriers Suppresses Cytokine-induced Catabolism Long Term, Osteoarthritis & Cartilage, 24(1), 2016, 71-81 LINK
- A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, A Rabbit Model Demonstrates the Influence of Cartilage Thickness on Intra-articular Drug Delivery and Retention within Cartilage, Journal of Orthopaedic Research, 33(5), 2015, 660-667 LINK
- A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, Electrostatic Interactions Enable Rapid Penetration, Enhanced Uptake and Retention of Intra-articular Injected Avidin in Rat Knee Joints, Journal of Orthopaedic Research, 32(8), 2014, 1044-1051 LINK
- A.G. Bajpayee, C.R. Wong, M.G. Bawendi, E.H. Frank, A.J. Grodzinsky, Avidin as a Model for Charge Driven Transport into Cartilage and Drug Delivery for Treating Early Stage PTOA, Biomaterials, 35(1), 2014, 538-549 LINK
Prof. Bajpayee works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Her lab utilizes concepts of nanomedicine and bio-electrostatics to design polypeptides and protein-based carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. Her lab is also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The group strives to combine basic science with translational research to develop biomedical technologies.
Research & Scholarship Interests
Department Research Areas
21 COE faculty and affiliates were recipients of FY18 TIER 1 Interdisciplinary Research Seed Grants for 12 different projects representing $600K dollars of investment in research.
BioE Assistant Professor Ambika Bajpayee (PI) and MIE/BioE Associate Professor Sandra Shefelbine (Collaborator) awarded a $310K DOD Peer Reviewed Medical Research Program Discovery Award