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a.bajpayee@northeastern.edu

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Ambika Bajpayee

216 ISEC
805 Columbus Avenue
Boston, MA 02115

Biography

Prof. Bajpayee works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Her lab utilizes concepts of nanomedicine and bio-electrostatics to design polypeptides and protein-based carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. Her lab is also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The group strives to combine basic science with translational research to develop biomedical technologies.

Education

  • PhD, Mechanical Engineering, Massachusetts Institute of Technology, 2015
  • MEng, Mechanical Engineering, Massachusetts Institute of Technology, 2007
  • BS, Mechanical Engineering, University of Delhi, 2006

Research & Scholarship Interests

Targeted drug delivery to avascular connective tissues; polypeptide and protein based nanocarriers; bio-electrostatics; transport phenomena in biological systems; biomechanics; post-traumatic osteoarthritis
Affiliated With

Department Research Areas

Teaching Interests

  • BIOE 5650, Multiscale Biomechanics
  • BIOE5651, Fields, Forces and Flows

Professional Affiliations

  • Osteoarthritis Research Society International (OARSI)
  • Orthopaedic Research Society (ORS)
  • Society for Biomaterials (SFB)
  • Biomedical Engineering Society (BMES)

 

Selected Publications

  • A.G. Bajpayee, R.E. De La Vega, M Scheu, N.H. Varady, I.A. Yannatos, L.A. Brown et al, Sustained Intra-cartilage Delivery of Low Dose Dexamethasone using a Cationic Carrier for Treatment of Post-traumatic Osteoarthritis, European Cell & Materials, 2017 LINK
  • A.G. Bajpayee, A.J. Grodzinsky, Cartilage Targeting Drug Delivery: Can Electrostatic Interactions help?, Nature Rheumatology Reviews, 2017 LINK
  • A.G. Bajpayee, M.A. Quadir, P.T. Hammond, A.J. Grodzinsky, Charge Based Intra-cartilage Delivery of Single Dose Dexamethasone Using Avidin Nano-carriers Suppresses Cytokine-induced Catabolism Long Term, Osteoarthritis & Cartilage, 24(1), 2016, 71-81 LINK
  • A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, A Rabbit Model Demonstrates the Influence of Cartilage Thickness on Intra-articular Drug Delivery and Retention within Cartilage, Journal of Orthopaedic Research, 33(5), 2015, 660-667 LINK
  • A.G. Bajpayee, A.M. Sheu, A.J. Grodzinsky, R.M. Porter, Electrostatic Interactions Enable Rapid Penetration, Enhanced Uptake and Retention of Intra-articular Injected Avidin in Rat Knee Joints, Journal of Orthopaedic Research, 32(8), 2014, 1044-1051 LINK
  • A.G. Bajpayee, C.R. Wong, M.G. Bawendi, E.H. Frank, A.J. Grodzinsky, Avidin as a Model for Charge Driven Transport into Cartilage and Drug Delivery for Treating Early Stage PTOA, Biomaterials, 35(1), 2014, 538-549 LINK

Related News

April 27, 2018

BioE Assistant Professor Ambika Bajpayee was awarded a $157k NIH grant for "Charge driven contrast enhanced computed tomography for imaging negatively charged tissues". The grant which will...

February 5, 2018

Working in the lab of BioE Assistant Professor Ambika Bajpayee, Erica Wagner has been on the front lines of the creation of a new method of treatment for intervertebral disc issues for which she recently received the Early Research and Creative Endeavor Award.

August 15, 2017

BioE Assistant Professor Ambika Bajapayee along with COS Assistant Professor Justin Crane propose to increase resilience in the aging population by developing novel ways of treating osteoarthritis (OA), the most common musculoskeletal disease and the leading cause of immobility.