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Lee Makowski received his B.S. at Brown University in Physics, and Masters and Ph.D. at Massachusetts Institute of Technology in Electrical Engineering. After doing postdoctoral research at Brandeis University in Structural Biology, he joined faculty of the College of Physician and Surgeons at Columbia University in the Biochemistry Department. He moved to Boston University as Professor of Physics and later accepted a position as Director of the Institute of Molecular Biophysics at Florida State University. In 1998 he joined the National Science Foundation where he was a Program Director first in the Biology Directorate and then in the Division of Materials Science. From 2000 until 2010 he was at Argonne National Laboratory, first as Biosciences Division Director and then as Senior Scientist. He moved to Northeastern in the fall of 2010. He is an author of over 100 scientific research papers and numerous review articles on innovative analyses of biophysical data with focus on x-ray and neutron scattering and x-ray imaging.


  • PhD, Massachusetts Institute of Technology, 1976

Research & Scholarship Interests

Image and signal processing as applied to biophysical data designed to answer fundamental questions about the molecular basis of living systems
Affiliated With

Department Research Areas

College Research Initiatives

Honors & Awards

  • 2017 Dean’s Award for Meritorious Service

Selected Publications

  • L. Makowski, et al. "Large-scale Inter-laboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-relevant Proteins in Plasma", Molecular and Cellular Proteomics, 14(4), 2015, 2357-2374 
  • Y. Wang, E. Onuk, L. Makowski "The Mechanism of Population Shifting Among Transition States of Adenylate Kinase", Biophysical Journal, 108(2), 2015, 59a
  • B. Donohoe, J. Matthews, M.E. Himmel, L. Makowski, et al. "Multiscale Deconstruction of Molecular Architecture in Corn Stover", Scientific Reports, 4(3756), 2014 
  • L. Makowski, H.R. Kim, P. Ciesielski, J. Badger, et al. "The Structure of the Catalytic Domain of a Plant Cellulose Synthase and its Assembly into Dimers", The Plant Cell, 26(7), 2014, 2996-3009 
  • R.E. Iacob, G.M. Bou-Assaf, L. Makowski, J.R. Engen, et al. "Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements", Journal of Pharmaceutical Sciences, 102(12), 2013, 4315-4329
See Google Scholar Profile for all publications »

Related News

December 5, 2017

BioE Professor Lee Makowski has been selected as a Fellow of the American Institute for Medical and Biological Engineering.

May 3, 2017

Congratulations to all the winners of the faculty and staff awards, and to everyone for their hard work and dedication during the 2016-2017 academic school year. Faculty Fellow Edward Beighley, CEE...

April 3, 2017

The grand opening ceremony for the new Interdisciplinary Science and Engineering Complex took place on April 3, 2017.