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L.Makowski@northeastern.edu

Profile

Lee Makowski

Professor and Chair, Bioengineering
Interdisciplinary with, Chemistry and Chemical Biology
617.373.3006
206 Lake Hall
360 Huntington Avenue
Boston, MA 02115

Biography

Lee Makowski received his B.S. at Brown University in Physics, and Masters and Ph.D. at Massachusetts Institute of Technology in Electrical Engineering. After doing postdoctoral research at Brandeis University in Structural Biology, he joined faculty of the College of Physician and Surgeons at Columbia University in the Biochemistry Department. He moved to Boston University as Professor of Physics and later accepted a position as Director of the Institute of Molecular Biophysics at Florida State University. In 1998 he joined the National Science Foundation where he was a Program Director first in the Biology Directorate and then in the Division of Materials Science. From 2000 until 2010 he was at Argonne National Laboratory, first as Biosciences Division Director and then as Senior Scientist. He moved to Northeastern in the fall of 2010. He is an author of over 100 scientific research papers and numerous review articles on innovative analyses of biophysical data with focus on x-ray and neutron scattering and x-ray imaging.

Education

  • PhD, Massachusetts Institute of Technology, 1976

Research & Scholarship Interests

Image and signal processing as applied to biophysical data designed to answer fundamental questions about the molecular basis of living systems
Affiliated With

Department Research Areas

College Research Initiatives

Selected Publications

  • L. Makowski, et al. "Large-scale Inter-laboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-relevant Proteins in Plasma", Molecular and Cellular Proteomics, 14(4), 2015, 2357-2374 
  • Y. Wang, E. Onuk, L. Makowski "The Mechanism of Population Shifting Among Transition States of Adenylate Kinase", Biophysical Journal, 108(2), 2015, 59a
  • B. Donohoe, J. Matthews, M.E. Himmel, L. Makowski, et al. "Multiscale Deconstruction of Molecular Architecture in Corn Stover", Scientific Reports, 4(3756), 2014 
  • L. Makowski, H.R. Kim, P. Ciesielski, J. Badger, et al. "The Structure of the Catalytic Domain of a Plant Cellulose Synthase and its Assembly into Dimers", The Plant Cell, 26(7), 2014, 2996-3009 
  • R.E. Iacob, G.M. Bou-Assaf, L. Makowski, J.R. Engen, et al. "Investigating Monoclonal Antibody Aggregation Using a Combination of H/DX-MS and Other Biophysical Measurements", Journal of Pharmaceutical Sciences, 102(12), 2013, 4315-4329
See Google Scholar Profile for all publications »

Related News

September 21, 2016

BioE Professor & Chair Lee Makowski is studying Alzheimer's progression to better develop treatments for the disease. Source: News @ Northeastern New research led by Northeastern University...

October 20, 2015

Parent/Family night was a success on Friday October 16, 2015 where students, families, faculty, and staff all came together in the Snell Engineering building. Some highlights include touring...

September 2, 2015

Written by Allan Wong, a BS student in Bioengineering.